Aldagen, Inc. (formerly StemCo Pharmaceuticals, Inc.) is a Durham, NC medical technology company, founded on March 2, 2000. Aldagen focuses on the development of products utilizing their proprietary patented technologies for identification and isolation of adult stem cell populations for use in treatment of cardiovascular, peripheral vascular and other regenerative medicine applications.

Arbovax, a Raleigh, NC company, is focused on the commercialization of a novel and innovative technology to facilitate the development of vaccines against insect-borne viruses. The initial focus includes Dengue Fever and Yellow Fever. Subsequent targets include Japanese Encephalitis and West Nile. The Piedmont Angel Network Two led the most recent funding round.

AvidXchange is a Charlotte, NC based software company that develops, markets and services web-based application for paperless invoice management and electronic procurement tools for companies with multiple properties. The company has extensive experience building “off-the-shelf” and custom interfaces to support customer implementations. Products include AvidBuy, AvidInvoice, Avid-VSAR, and UBAR.

Hispanic Media, Inc. (“Batanga”) is the largest Internet radio/media company focused on using Latin music and content unavailable elsewhere to reach its target, U.S. Hispanics between the ages of 12 and 34. Batanga’s competitive advantages include a dominant market position, market focus, experienced management, unique technology and low-cost operations.

BeliefNetworks was founded to assist businesses and organizations to transform real time, structured and unstructured data - such as marketing campaign data, customer behavior information and social network conversations - into actionable knowledge for improved customer experience. Products include DataChasm for harvesting, discovery and prediction, AffinityAgent for ad and content recommendations, DynamicDataAgent for secure information exchange across web boundaries or within enterprise, Public APIs for free and lightweight web integrations, and HashBrown browser plug-in for finding even more content. The Piedmont Angel Network Two led the most recent funding round.

Bioptigen, a Durham, NC company, has developed advanced technology, through patent and licensing agreements with Duke University, in the field of Optical Coherence Tomography (OCT). OCT enables a non-invasive, real-time two- and three-dimensional imaging of living subjects with resolution up to 100-times finer than 4D ultrasound techniques.

BrightView Technologies, Inc. is a Durham, NC company founded in June 2002 and is a leading developer of innovative, microstructure based, optical films for the global display industry. BrightView is introducing products for displays based on virtually all display technologies including LCD, Plasma, OLED, rear projection and front projection.

ContraVac is developing diagnostic and therapeutic products for male reproductive health as a result of research in male reproductive biology done at the Center for Research in Contraceptive and Reproductive Health (CRCRH) at UVA. Specifically two areas – Point of Care Sperm immunodiagnostic tests for use at home or in the clinic (SpermCheck) and Spermistatic Cream.

Extend Energy, Greensboro, NC, designs and delivers solar energy systems to commercial customers with the goal of energy cost reduction and positive environmental impact. The Piedmont Angel Network Two led the most recent funding round.

Kucera Pharmaceutical Company is based in Winston-Salem, NC. The company started with a drug delivery approach that combined or conjugated delivery molecules with therapeutic molecules as a platform technology, both to improve the properties of the attached therapeutic molecules (making them orally available and improving distribution) and to extend patent life.

LiveCargo, Inc. is a software company founded in July 2003. The Company provides productivity tools focused on seamless mobility for the individualized workforce. As an applications service provider, the Company has proprietary, patent-pending technology that enables mobile users to share and collaborate on documents and digital media using smart phones, PCs and other wireless computing devices. LiveCargo operates from two data centers located in Singapore and Washington, D.C.

Merscom is a global publisher of computer and video games that distributes through multiple channels, multiple platforms and multiple revenue models. Merscom's channels include retail distribution in the US and Europe, online sales through major portals worldwide, and games on Microsoft® Xbox Live® Arcade. Merscom publishes games from leading casual game developers on multiple platforms including PC, console and handheld devices. Merscom produces entertaining products for gamers of all ages. The Piedmont Angel Network Two led the most recent funding round.

Optivia Medical is a Winston-Salem, NC biotech company founded in 2004 that develops and commercializes patented products for use in endoscopic medicine. The first product, a hysteroscope with an introducer, steerable working channel, and visually guided dilator has reached the final stage of prototype production.

Piedmont Pharmaceuticals, based in Greensboro, NC, is a drug development company that is developing and marketing through license agreements a product for treating head lice, has licensed a product for exterminating fly eggs/larvae in horse manure and is developing a product to alleviate middle ear infections as well as a nutriceutical topical analgesic.

Pique Therapeutics, based in Durham, NC, is a biotechnology company seeking to become the leading therapeutic vaccine company, focused initially on the treatment of cancer. Pique's lead product is a first-in-class therapeutic vaccine (PT 107) for the treatment of non-small cell lung cancer (NSCLC). PT 107 has completed Phase 1 clinical trials, was well-tolerated, and had an excellent safety profile in cancer patients. PT 107 showed a 134% improvement in median survival (11 months) for patients with late-stage NSCLC, as compared with the expected 4 to 6 months. Remarkably, almost 25% of the patients are still alive and in remission after 3 years. PT 107 is currently in a two-arm, double-blind Phase 2 study, to further examine the safety and efficacy of the drug. The Piedmont Angel Network Two led the most recent funding round.

Protochips, based in Raleigh, NC, creates the world's most advanced holders, stages and specimen supports for electron microscopy using the tools and techniques of semiconductor manufacturing. These novel capabilities are integrated into all of the products developed and manufactured. As a result, Protochip's products enable the highest resolution of nanostructures in their native environments and have proven themselves to be of enormous value in both Life Science and Materials Science applications all the way from R&D through product Q/A. The Piedmont Angel Network Two led the most recent funding round.

Raw Essentials is a skin care products line company that doesn't use any irritating petrochemicals, parabens, preservatives, synthetic additives or fillers. The line was developed by Carol Alt and is Certified Raw. The Piedmont Angel Network Two led the most recent funding round.

Sandbox Learning, Inc. is a Cornelius, NC based company founded in 2003 as a web-based company that supplies educational products to parents and professionals working with children with developmental disabilities.

Sensory Analytics is an emerging leader in the development of optical, RF and related sensory solutions for color and thickness measurement, quality assurance and process control applications. The Company provides its information technology solution to global manufacturers that are seeking to reduce their costs associated with manufacturing labor and quality, while also increasing their production throughput.

Southeast TechInventures is a technology accelerator for the rapid conversion of university scientific breakthroughs into products, services and new technology companies. STI works with university-based inventors to accelerate the commercialization of technologies and intellectual property in biotechnology (medical devices, bioengineering), display technology, IT, and nanotechnology.